Análisis de fiabilidad y concordancia entre 5 métodos subjetivos de medición de la torsión ocular / Reliability and agreement analysis among 5 subjective methods of ocular torsion measurement

Objetivo Evaluar la fiabilidad en la medición de la torsión ocular y la concordancia de los siguientes métodos subjetivos: test de Maddox bilateral, sinoptóforo, torsionómetro de Gracis, pantalla de Harms y test de ciclodesviaciones de Awaya. Método Se seleccionaron pacientes con estrabismo vertical adquirido en la edad adulta y se realizó la medición de la torsión ocular con los 5 métodos descritos en 3 ocasiones. Al no existir un gold standard en la medición subjetiva de la torsión ocular, se eligió como prueba de referencia aquella que obtuviera mejores datos de repetibilidad. Resultados Veinticinco pacientes fueron incluidos en el estudio. Se estudió la repetibilidad de cada prueba: test de Maddox bilateral (CCI=0,783, CV=29,33%), sinoptóforo (CCI=0,976, CV=6,71%), torsionómetro de Gracis (CCI=0,937, CV=20,10%), pantalla de Harms (CCI=0,962, CV=11,86%) y test de Awaya (CCI=0,987, CV=52,58%). La prueba de referencia para comparar la concordancia fue el sinoptóforo. Se encontraron diferencias estadísticamente significativas al comparar los rangos de torsión ocular entre el sinoptóforo y el torsionómetro de Gracis (p=0,008) y entre el sinoptóforo y el test de Awaya (p=0,02). Conclusiones El test de Maddox bilateral, el sinoptóforo, el torsionómetro de Gracis y la pantalla de Harms son métodos fiables con buenos índices de reproducibilidad. Entre ellos, el sinoptóforo es el método más consistente. El test de Awaya no demostró buena fiabilidad. El test de Maddox bilateral, el torsionómetro de Gracis y la pantalla de Harms fueron métodos con buena concordancia con el sinoptóforo, que se determinó como test de referencia. El test de Awaya no demostró buena concordancia con el sinoptóforo (AU)

Objective To evaluate the reliability in the measurement of ocular torsion and the agreement of the following subjective methods: double Maddox test, synoptophore, Gracis torsionometer, Harms screen and Awaya cyclodeviation test. Method Patients with vertical strabismus acquired in adulthood were recruited and ocular torsion was measured with the 5 methods described on 3 occasions. As a gold standard test does not exist, the one that obtained the best repeatability data was chosen as the reference test. Results Twenty-five patients were included in the study. The repeatability of each test was studied: double Maddox test (ICC=0.783, CV=29.33%), synoptophore (ICC=0.976, CV=6.71%), Gracis torsionometer (ICC=0.937, CV=20.10%), Harms screen (ICC=0.962, CV=11.86%) and Awaya test (ICC=0.987, CV=52.58%). The reference test to compare the agreement was the synoptophore. Statistically significant differences were found when comparing the ocular torsion ranges between the synoptophore and the Gracis torsionometer (P=.008) and between the synoptophore and the Awaya test (P=.02). Conclusion The double Maddox test, the synoptophore, the Gracis torsionometer, and the Harms screen are reliable methods with good reproducibility indices. Among them, the synoptophore is the most consistent method. The Awaya test did not show good reliability. The bilateral Maddox test, the Gracis torsionometer, and the Harms screen were methods with good agreement with the synoptophore, which was determined as the reference test. The Awaya test did not show good agreement with the synoptophore (AU)

Reliability and agreement analysis among 5 subjective methods of ocular torsion measurement.

OBJECTIVE: To evaluate the reliability in the measurement of ocular torsion and the agreement of the following subjective methods: double Maddox test, synoptophore, Gracis torsionometer, Harms screen and Awaya cyclodeviation test. METHOD: Patients with vertical strabismus acquired in adulthood were recruited and ocular torsion was measured with the 5 methods described on three occasions. As a gold standard test does not exist, the one that obtained the best repeatability data was chosen as the reference test. RESULTS: 25 patients were included in the study. The repeatability of each test was studied: double Maddox test (ICC = 0.783, CV = 29.33%), synoptophore (ICC = 0.976, CV = 6.71%), Gracis torsionometer (ICC = 0.937, CV = 20.10%), Harms screen (ICC = 0.962, CV = 11.86%) and Awaya test (ICC = 0.987, CV = 52.58%). The reference test to compare the agreement was the synoptophore. Statistically significant differences were found when comparing the ocular torsion ranges between the synoptophore and the Gracis torsionometer (p = 0.008) and between the synoptophore and the Awaya test (p = 0.02). CONCLUSIONS: The double Maddox test, the synoptophore, the Gracis torsionometer, and the Harms screen are reliable methods with good reproducibility indices. Among them, the synoptophore is the most consistent method. The Awaya test did not show good reliability. The bilateral Maddox test, the Gracis torsionometer, and the Harms screen were methods with good agreement with the synoptophore, which was determined as the reference test. The Awaya test did not show good agreement with the synoptophore.

Satisfacción de la cirugía de estrabismo basada en la opinión de cirujanos expertos / Satisfaction with strabismus surgery based on the opinion of expert surgeons

OBJETIVO: El objetivo es valorar la percepción de los cirujanos de estrabismo en España sobre la satisfacción de los pacientes tras la cirugía, analizando cuáles consideran que son los tipos de estrabismo con pacientes más satisfechos y las causas de insatisfacción. MÉTODO: Se realizó una encuesta a los miembros de la Sociedad Española de Estrabología mayores de 50 años, que estuvieran en activo y cuya principal actividad quirúrgica fuera la cirugía de estrabismo, con ejercicio de su profesión en España y más de 20 años de experiencia quirúrgica. La encuesta constaba de 18 preguntas acerca de la percepción de la satisfacción de los pacientes según el tipo de estrabismo, la edad del paciente y la causa de insatisfacción más frecuente tras la cirugía. RESULTADOS: Se incluyeron 29 encuestas de cirujanos con una experiencia quirúrgica media de 31 años. La causa de insatisfacción percibida más frecuente fue el estrabismo residual. No se encontraron diferencias en el índice de satisfacción entre niños y adultos. La cirugía que consideran que produce mayor satisfacción es la endotropía, seguida de la parálisis del IV par descompensada y la exotropía, mientras que la parálisis del III par craneal es la que más descontento causa. CONCLUSIONES: Según la opinión de los cirujanos, la cirugía de la endotropía es la más satisfactoria para el paciente seguida de la exotropía, los estrabismos verticales y la parálisis traumática del IV par craneal

PURPOSE: To assess the perception of strabismus surgeons in Spain regarding patient satisfaction after surgery, by analysing the types of strabismus with the most satisfied patients, as well as the causes of dissatisfaction. METHODS: A survey was carried out among the members of the Spanish Strabology Society who were over 50 years of age, active in Spain, with more than 20 years of surgical experience, and whose main surgical activity was strabismus. The questionnaire consisted of 18 questions about the perception of patient satisfaction according to the type of strabismus, patient age, as well as the most frequent cause of dissatisfaction after surgery. RESULTS: The questionnaires were completed by a total of 29 surgeons, with a mean of 31 years of surgical experience. The most frequent cause of perceived dissatisfaction was residual strabismus. No differences were found in the satisfaction index between children and adults. The surgery that was considered to produce greater satisfaction was endotropia, followed by decompensated 4th nerve palsy, and exotropia, while 3rd nerve palsy was the cause of the most dissatisfaction. CONCLUSIONS: According to strabismus surgeons, endotropia is the most satisfactory surgery for the patient, followed by exotropia, vertical strabismus, and traumatic paralysis of the 4th cranial nerve

Satisfaction with strabismus surgery based on the opinion of expert surgeons. / Satisfacción de la cirugía de estrabismo basada en la opinión de cirujanos expertos.

PURPOSE: To assess the perception of strabismus surgeons in Spain regarding patient satisfaction after surgery, by analysing the types of strabismus with the most satisfied patients, as well as the causes of dissatisfaction. METHODS: A survey was carried out among the members of the Spanish Strabology Society who were over 50 years of age, active in Spain, with more than 20 years of surgical experience, and whose main surgical activity was strabismus. The questionnaire consisted of 18 questions about the perception of patient satisfaction according to the type of strabismus, patient age, as well as the most frequent cause of dissatisfaction after surgery. RESULTS: The questionnaires were completed by a total of 29 surgeons, with a mean of 31 years of surgical experience. The most frequent cause of perceived dissatisfaction was residual strabismus. No differences were found in the satisfaction index between children and adults. The surgery that was considered to produce greater satisfaction was endotropia, followed by decompensated 4th nerve palsy, and exotropia, while 3rd nerve palsy was the cause of the most dissatisfaction. CONCLUSIONS: According to strabismus surgeons, endotropia is the most satisfactory surgery for the patient, followed by exotropia, vertical strabismus, and traumatic paralysis of the 4th cranial nerve.

Estudio de correlación en las medidas de ducciones pasivas oblicuas y de ciclorrotación / Correlation study in the measurements of oblique passive ductions and cyclorotation

OBJETIVO: Evaluar la repetibilidad intraobservador e interobservador de la «prueba de ducción forzada exagerada» o «prueba de tracción oblicua» y la «prueba de exciclo e inciclorrotación pasiva» o «prueba de tracción de ciclorrotación». MATERIALES Y MÉTODOS: Se estudiaron 44 ojos de 22 pacientes. Fueron evaluados bajo anestesia general profunda. La ducción pasiva se probó en supraducción e infraducción mediante la «prueba de ducción exagerada». La limitación en el movimiento se graduó de 0 a -4. La prueba de ciclorrotación pasiva se evaluó con retropulsión del globo hasta que se observa la primera resistencia. Utilizamos el anillo de Méndez y los puntos azules marcados en el limbo para medir la cantidad de ciclorrotación. Se registraron los resultados obtenidos de exciclo e inciclorrotación. Todas las mediciones se realizaron por duplicado para cada uno de los 2 observadores. RESULTADOS: El coeficiente de correlación intraclase de la «prueba de tracción oblicua» entre los 2 observadores para el oblicuo inferior fue 0,738 (intervalo de confianza del 95%, 0,62-0,83) y 0,910 para el oblicuo superior (intervalo de confianza del 95%, 0,85-0,94). El coeficiente de correlación intraclase de «prueba de tracción de ciclorrotación» de los 2 observadores fue de 0,827 (intervalo de confianza del 95%, 0,74-0,89) para excicloducción y 0,792 (intervalo de confianza del 95%, 0,67-0,85) para incicloducción. El porcentaje de pacientes dentro de 5̊ de rotación interobservador fue de 84,1% para exciclo y 81,8% para inciclorrotación. Ambas pruebas tuvieron una mejor correlación intraobservador que en la evaluación interobservador. CONCLUSIONES: La evaluación de «prueba de tracción oblicua» y «prueba de tracción de ciclorrotación» tuvo una correlación de moderada a buena entre los 2 observadores y buena a excelente en la evaluación intraobservador

PURPOSE: To evaluate intraoserver and inteobserver repeatability of the "exaggerated forced duction test" or "oblique traction test" and the "excyclo and incyclo passive rotation test" or "cyclorotation traction test". METHODS: 44 eyes of 22 patients were evaluated under deep general anesthesia. Passive duction was tested on supraduction and infraduction by the "exaggerated duction test". The limitation on movement was graduated from 0 to - 4. Passive cyclorotation test was evaluated with retropulsion of the globe until the first resistance is noted. We used the Mendez ring and blue dots marked on the limbus to measure the amount of cyclorotation. The results obtained of excyclo and incyclorotation were recorded. All measurements were made in duplicate for each of the two observers. RESULTS: The intraclass correlation of the "oblique traction test" coefficient between the two observers was for the IO was 0,738 (95% confidence interval, 0,62-0,83) and 0,910 for the superior oblique (SO) (95% confidence interval, 0,85-0,94). The "cyclorotation traction test" intraclass correlation coefficient of the between the two observers was 0,827 (95% confidence interval, 0,74-0,89) for exclycloduction and 0,792 (95% confidence interval, 0,67-0,85) for inclycloduction. The percentage of patients within 5° of rotation interobserver was 84,1% for excyclorotation and 81,8% for inclyclorotation. Both tests had better correlation on the intraobserver than interobserver evaluation. CONCLUSIONS: Evaluation of the "oblique traction test" and "cyclorotation traction test" had moderate to good correlation between the two observers and good to excellent on the intraobserver evaluation

Parálisis oculomotoras en el contexto de una reactivación del virus varicela-zóster: a propósito de 4 casos / Oculomotor nerve palsy in herpes zoster ophthalmicus: Presentation of 4 cases

La infección por el virus varicela-zóster (VVZ) tiene una alta prevalencia a nivel mundial. De las muchas manifestaciones oftalmológicas que puede manifestar, la diplopía de aparición brusca es una de ellas. Revisamos 4 casos clínicos de mononeuritis del III y VI par craneales en el contexto de vesículas herpéticas por el VVZ y revisamos la fisiopatología y las manifestaciones clínicas más importantes. Es obligado para el oftalmólogo descartar complicaciones mediante pruebas de imagen y el correcto tratamiento con antivirales sistémicos

Varicella zoster virus (VZV) infection has a high prevalence worldwide. Within the multiple ophthalmologic manifestations that VZV can cause, sudden diplopia is among them. A review is presented of four clinical cases of 3rd and 4th oculomotor nerve palsies in herpes zoster ophthalmicus. A review is also presented of the physiopathology and most important clinical manifestations. Imaging tests are essential in order to rule out complications. Systemic antiviral administration is the correct treatment

Correlation study in the measurements of oblique passive ductions and cyclorotation. / Estudio de correlación en las medidas de ducciones pasivas oblicuas y de ciclorrotación.

PURPOSE: To evaluate intraoserver and inteobserver repeatability of the "exaggerated forced duction test" or "oblique traction test" and the "excyclo and incyclo passive rotation test" or "cyclorotation traction test". METHODS: 44 eyes of 22 patients were evaluated under deep general anesthesia. Passive duction was tested on supraduction and infraduction by the "exaggerated duction test". The limitation on movement was graduated from 0 to - 4. Passive cyclorotation test was evaluated with retropulsion of the globe until the first resistance is noted. We used the Mendez ring and blue dots marked on the limbus to measure the amount of cyclorotation. The results obtained of excyclo and incyclorotation were recorded. All measurements were made in duplicate for each of the two observers. RESULTS: The intraclass correlation of the "oblique traction test" coefficient between the two observers was for the IO was 0,738 (95% confidence interval, 0,62-0,83) and 0,910 for the superior oblique (SO) (95% confidence interval, 0,85-0,94). The "cyclorotation traction test" intraclass correlation coefficient of the between the two observers was 0,827 (95% confidence interval, 0,74-0,89) for exclycloduction and 0,792 (95% confidence interval, 0,67-0,85) for inclycloduction. The percentage of patients within 5° of rotation interobserver was 84,1% for excyclorotation and 81,8% for inclyclorotation. Both tests had better correlation on the intraobserver than interobserver evaluation. CONCLUSIONS: Evaluation of the "oblique traction test" and "cyclorotation traction test" had moderate to good correlation between the two observers and good to excellent on the intraobserver evaluation.

Oculomotor nerve palsy in herpes zoster ophthalmicus: Presentation of 4 cases. / Parálisis oculomotoras en el contexto de una reactivación del virus varicela-zóster: a propósito de 4 casos.

Varicella zoster virus (VZV) infection has a high prevalence worldwide. Within the multiple ophthalmologic manifestations that VZV can cause, sudden diplopia is among them. A review is presented of four clinical cases of 3rd and 4th oculomotor nerve palsies in herpes zoster ophthalmicus. A review is also presented of the physiopathology and most important clinical manifestations. Imaging tests are essential in order to rule out complications. Systemic antiviral administration is the correct treatment.

Manifestaciones neuroftalmológicas como complicación de una infección por Mycoplasma pneumoniae y desarrollo posterior de una encefalitis aguda diseminada / Neuro-ophthalmological manifestations as complication of an infection with Mycoplasma pneumoniae and subsequent development of disseminated acute encephalitis

El objetivo es describir dos cuadros clínicos neuroftalmológicos en niños por infección sistémica por Mycoplasma pneumoniae (M. pneumoniae). Se presentan los casos de dos niñas de 14 y 12 años que acudieron a urgencias: la primera con oftalmoplejía internuclear y la segunda con pérdida de visión y cefalea. No presentaban otra focalidad neurológica. En la imagen de resonancia magnética se evidenciaron placas hiperintensas en ambas, sugerentes de cuadro desmielinizante. Al mes, los síntomas neuroftalmológicos se resolvieron y las resonancias magnéticas de control fueron normales. El diagnóstico fue encefalitis diseminada aguda secundaria a M. pneumoniae. El diagnóstico se hace por PCR (gold standard) y/o IgM en serología. Es importante pensar en esta posible etiología ante casos sugerentes de enfermedad desmielinizante. Existe controversia sobre el papel de los antibióticos y si se contemplan los corticoides. Como conclusión, M. pneumoniae debe ser diagnóstico diferencial en afectaciones neuroftalmológicas agudas en niños

The purpose of this article is to describe two paediatric neuro-ophthalmological clinical cases caused by a systemic infection due to Mycoplasma pneumoniae (M. pneumoniae). The cases are two girls aged 14 and 12 seen in the Emergency Department: The first one had internuclear ophthalmoplegia and second with loss of vision and headache. They had no other neurological foci. Magnetic resonance imaging showed hyperintense plaques in both, suggestive of a demyelinating disease. One month later, the neuro-ophthalmological symptoms resolved, with normal follow-up magnetic resonance imagings. The diagnosis was acute disseminated encephalitis secondary to M. pneumoniae. The diagnosis was made using PCR (gold standard) and/or IgM in serology. It is important to think about this possible aetiology in cases of suggestive demyelinating disease. There is controversy about the role of antibiotics and on whether corticosteroids are contemplated. In conclusion, M. pneumoniae must be a differential diagnosis in acute neuro-ophthalmological disorders in children

Neuro-ophthalmological manifestations as complication of an infection with Mycoplasma pneumoniae and subsequent development of disseminated acute encephalitis. / Manifestaciones neuroftalmológicas como complicación de una infección por Mycoplasma pneumoniae y desarrollo posterior de una encefalitis aguda diseminada.

The purpose of this article is to describe two paediatric neuro-ophthalmological clinical cases caused by a systemic infection due to Mycoplasma pneumoniae (M. pneumoniae). The cases are two girls aged 14 and 12 seen in the Emergency Department: The first one had internuclear ophthalmoplegia and second with loss of vision and headache. They had no other neurological foci. Magnetic resonance imaging showed hyperintense plaques in both, suggestive of a demyelinating disease. One month later, the neuro-ophthalmological symptoms resolved, with normal follow-up magnetic resonance imagings. The diagnosis was acute disseminated encephalitis secondary to M. pneumoniae. The diagnosis was made using PCR (gold standard) and/or IgM in serology. It is important to think about this possible aetiology in cases of suggestive demyelinating disease. There is controversy about the role of antibiotics and on whether corticosteroids are contemplated. In conclusion, M. pneumoniae must be a differential diagnosis in acute neuro-ophthalmological disorders in children.

Development of Ureteral Stenosis/Obstruction in Kidney Transplant.

This retrospective study describes the incidence and prevalence of ureteral stenosis/obstruction (US/O) in a cohort of 334 renal transplants recipients in our center over the last 5 years and evaluates the risk factors that may influence the occurrence of US/O. The parameters studied included the following: history of prostate disease, smoking, urinary tract infection, renal lithiasis, ureterovesical reflux, presence and level of polar artery, type of ureterovesical anastomosis, delayed graft function, double J catheter, lymphocele, urinoma, acute rejection, prolonged catheterization, post-transplant infravesical obstruction and BK virus infection, age of the donor and recipient, and months on dialysis. Also evaluated were the nadir creatinine and instances of cold ischemia, asystole, reanastomosis, and double J catheter removal. The average incidence of US/O was 7.6% and was significantly correlated with factors of alteration of the uretero-bladder dynamics without finding a relation to vascular factors.

Fecaloma como causa de fracaso renal agudo / Fecaloma as a cause of acute renal failure

No disponible

Estudio de la calidad de vida y la función visual en niños con glaucoma en España / Quality of life and visual function in children with glaucoma in Spain

Objetivo: Evaluar el efecto del glaucoma en la función visual, la calidad de vida en los niños y la calidad de vida percibida por los cuidadores en niños de hasta 16 años. Material y métodos: Se diseñó un estudio observacional y prospectivo. Se aplicó el cuestionario GQL-15 (Glaucoma Quality of Life) a los niños y a los cuidadores, y el cuestionario VFQ-25 (Visual Functioning Questionnarie) a los niños. Se registraron diferentes variables de la historia clínica que podrían influir en la calidad de vida y la función visual. Resultados: Se incluyó a un total de 24 pacientes con una edad media de 9,13 ± 3,08 años, de los cuales 3 tenían afectación unilateral y 20 presentaban glaucoma congénito primario. Los padres reportaron una peor calidad de vida que los niños: el resultado de la encuesta GQL-15 fue de 32,30 ± 11,56 puntos en los niños y de 37,5 2 ± 14,59 puntos en los cuidadores (p = 0,001). El parámetro que más se relacionó con la calidad de vida y la función visual fue el defecto medio del campo visual en el mejor ojo. Se encontró una correlación estadísticamente significativa entre el resultado de GQL-15 y el defecto medio del campo visual (niños: R = 0,63; p < 0,01 y cuidadores: R = 0,81; p < 0,001). Conclusiones: El daño funcional visual producido por el glaucoma tiene un impacto importante en la calidad de vida y en la función visual de los niños con glaucoma, si bien la calidad de vida percibida por los cuidadores es peor que la percibida por el niño

Objective: To evaluate the effect of glaucoma on visual function, as well as quality of life in children and quality of life perceived by caregivers in children up to 16 years of age. Material and methods: An observational and prospective study was designed using the questionnaire GQL-15 (Glaucoma Quality of Life) and conducted on children and caregivers. The questionnaire VFQ-25 (Visual Functioning Questionnaire) was conducted on children. Different variables of the clinical history that could influence the quality of life and visual function were recorded. Results: The study included 24 patients with a mean age of 9.13 ± 3.08 years, and included 3 with unilateral involvement, and 20 diagnosed with primary congenital glaucoma. Parents reported a worse quality of life than children. The result of the GQL-15 survey was 32.3 ± 11.56 points in children and 37.52 ± 14.59 points in caregivers (P = .001). The parameter most related to quality of life and visual function was the mean deviation (MD) of the visual field in the best eye. A statistically significant correlation was found between the result of GQL-15 and the mean deviation of the visual field (children: R = 0.63, P < .01, caregivers: R= 0.81, P < .001). Conclusions: Functional loss has an impact on the quality of life and visual function in children with glaucoma, although the quality of life perceived by the caregivers is worse than that perceived by the child

Quality of life and visual function in children with glaucoma in Spain. / Estudio de la calidad de vida y la función visual en niños con glaucoma en España.

OBJECTIVE: To evaluate the effect of glaucoma on visual function, as well as quality of life in children and quality of life perceived by caregivers in children up to 16 years of age. MATERIAL AND METHODS: An observational and prospective study was designed using the questionnaire GQL-15 (Glaucoma Quality of Life) and conducted on children and caregivers. The questionnaire VFQ-25 (Visual Functioning Questionnaire) was conducted on children. Different variables of the clinical history that could influence the quality of life and visual function were recorded. RESULTS: The study included 24 patients with a mean age of 9.13±3.08 years, and included 3 with unilateral involvement, and 20 diagnosed with primary congenital glaucoma. Parents reported a worse quality of life than children. The result of the GQL-15 survey was 32.3±11.56 points in children and 37.52±14.59 points in caregivers (P=.001). The parameter most related to quality of life and visual function was the mean deviation (MD) of the visual field in the best eye. A statistically significant correlation was found between the result of GQL-15 and the mean deviation of the visual field (children: R=0.63, P<.01, caregivers: R=0.81, P<.001). CONCLUSIONS: Functional loss has an impact on the quality of life and visual function in children with glaucoma, although the quality of life perceived by the caregivers is worse than that perceived by the child.

Severe Scedosporium apiospermum Infection in a Recent Renal Transplant Recipient: Case Report.

Infections in transplanted patients are still an important cause of morbidity and mortality. Among them, fungal infections with pathogens have become increasingly more prevalent in the last decade. We report the clinical course and management of disseminated Scedosporium apiospermum infection in a kidney transplant recipient, with microbiological isolation of the fungus in cerebrospinal fluid culture. S apiospermum is a fungus that is distributed worldwide and can be grown from soil samples or stagnant water. Disseminated infection is the most frequent form of infection, with cerebral involvement in most cases, which leads to a very high mortality (around 75%). Post-transplant renal infections require a thorough evaluation. Specifically, a high suspicion index is necessary, considering Scedosporium infection among the differential diagnosis of invasive fungal diseases in renal transplantation patients. It is essential to confirm the microbiological diagnosis for an adequate diagnosis and treatment.

[Use of botulinum toxin in a patient with pendular congenital nystagmus]. / Empleo de toxina botulínica en paciente con nistagmus congénito de tipo pendular.

CASE REPORT: We report the case of a 5 month-old male diagnosed with congenital nystagmus and oculocutaneous albinism. The initial examination showed pendular horizontal nystagmus with high amplitude and without blocking position or foveal fixation periods. A 2.5 IU injection of botulinum toxin was administered in the horizontal rectus muscles of both eyes in two sessions separated by 6 weeks. This led to a decrease in amplitude of nystagmus and early development of binocular visual acuity of 4.8cycles/cm. CONCLUSION: Faced with diagnosis of horizontal nystagmus in the early stages of development, and in order to avoid periods of foveal fixation, the use of botulinum toxin leads to a temporary reduction in its amplitude and an improvement in visual acuity with low complication rates. Given the possibility of spontaneous improvement described in these patients, studies are needed with longer follow-up to establish the advantage of long term treatment.

Empleo de toxina botulínica en paciente con nistagmus congénito de tipo pendular / Use of botulinum toxin in a patient with pendular congenital nystagmus

Caso clínico: Se presenta el caso de un varón de 5 meses de edad, diagnosticado de nistagmus congénito y albinismo oculocutáneo. En la exploración inicial se evidenció un nistagmus horizontal pendular de gran amplitud sin posición de bloqueo ni períodos de fijación foveal. Se realizó una inyección de 2,5 UI de toxina botulínica en los músculos rectos horizontales de ambos ojos en dos sesiones separadas por 6 semanas permitiendo una disminución de la amplitud del nistagmus y un desarrollo inicial de la agudeza visual binocular de 4,8 ciclos/cm. Conclusión: Ante el diagnóstico de nistagmus horizontal en etapas precoces del desarrollo, de amplitud tal que impida períodos de fijación foveal, el empleo de toxina botulínica permite una disminución temporal en la amplitud del mismo y una mejoría de la agudeza visual con baja tasa de complicaciones. Ante la posibilidad descrita de mejoría espontánea de estos pacientes, especialmente durante el primer año de vida, son necesarios estudios con mayor tiempo de seguimiento para establecer la ventaja de este tratamiento a largo plazo(AU)

Case report: We report the case of a 5 month-old male diagnosed with congenital nystagmus and oculocutaneous albinism. The initial examination showed pendular horizontal nystagmus with high amplitude and without blocking position or foveal fixation periods. A 2.5 IU injection of botulinum toxin was administered in the horizontal rectus muscles of both eyes in two sessions separated by 6 weeks. This led to a decrease in amplitude of nystagmus and early development of binocular visual acuity of 4.8 cycles/cm. Conclusion: Faced with diagnosis of horizontal nystagmus in the early stages of development, and in order to avoid periods of foveal fixation, the use of botulinum toxin leads to a temporary reduction in its amplitude and an improvement in visual acuity with low complication rates. Given the possibility of spontaneous improvement described in these patients, studies are needed with longer follow-up to establish the advantage of long term treatment(AU)

Competitive Brownian and Lévy walkers.

Population dynamics of individuals undergoing birth and death and diffusing by short- or long-range two-dimensional spatial excursions (Gaussian jumps or Lévy flights) is studied. Competitive interactions are considered in a global case, in which birth and death rates are influenced by all individuals in the system, and in a nonlocal but finite-range case in which interaction affects individuals in a neighborhood (we also address the noninteracting case). In the global case one single or few-cluster configurations are achieved with the spatial distribution of the bugs tied to the type of diffusion. In the Lévy case long tails appear for some properties characterizing the shape and dynamics of clusters. Under nonlocal finite-range interactions periodic patterns appear with periodicity set by the interaction range. This length acts as a cutoff limiting the influence of the long Lévy jumps, so that spatial configurations under the two types of diffusion become more similar. By dividing initially everyone into different families and following their descent it is possible to show that mixing of families and their competition is greatly influenced by the spatial dynamics.